Hyperlipidemia, Obese
Conditions
Keywords
obese women, high LDL-C
Brief summary
Green tea is one of the most popular beverages in the world. It is believed to have beneficial effect in prevention and treatment of many diseases, one of which is reducing LDL-C. The aim of the study is to examine the effect of supplement containing GTE on obese with high LDL level.
Detailed description
Randomized, double-blind, crossover placebo-controlled clinical trial
Interventions
DIETARY_SUPPLEMENTgreen tea extract
500 mg three times per day
DIETARY_SUPPLEMENTPlacebo
cellulose 500mg three times a day for 6 weeks
Sponsors
Taipei City Hospital
National Yang Ming Chiao Tung University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. age between 18 and 65 years 2. body mass index (BMI) \>= 27 kg/m2 3. fasting low-density-lipoprotein cholesterol (LDL) \>= 130mg/dl and (4) willing to participate in this trial.
Exclusion criteria
1. serum alanine transaminase \> 80 U/L 2. serum creatinine \> 1.8 mg/dl 3. breast feeding or pregnancy 4. heart failure, acute myocardial infarction, stroke, heavy injury 5. any other conditions not suitable for trial as evaluated by the physician. -
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| percentage of reduction of LDL-C | 6 weeks of treatment | level of LDL-C before intervention minus level of LDL-C after intervention equal to reduction of LDL-C, percentage of reduction of LDL-C equal to the level of reduction of LDL-C divided by level of LDL-C before intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| HDL-C | 6 weeks | serum level of high density lipoprotein cholesterol |
Countries
Taiwan
Outcome results
None listed