HIV-1 Infection
Conditions
Brief summary
The bacterial diversity of HIV patients digestive microbiota seropositive is poorly understood, it remains to be defined.
Interventions
OTHERPhysiopathology study
Sponsors
ANRS, Emerging Infectious Diseases
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient aged 18 or more. * Patients with a confirmed diagnosis of HIV infection 1. * Patient who signed an informed consent form. * Patient affiliated or beneficiary of a social security system.
Exclusion criteria
* Patient known to be suffering from inflammatory bowel disease (Crohn's disease or ulcerative colitis). * Patient HIV-2 or HIV-1/HIV-2 co-infected * Patient having received immunotherapy * Patient participating in another research. * Pregnant women, parturient or lactating person under guardianship, or deprived of liberty by a judicial or administrative decision.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion and type of OTU (Operational Taxonomic Unit) assigned to the rank of phylum genus and species of bacteria in the intestinal microbiota of HIV-1 seropositive patients. | Baseline |
Secondary
| Measure | Time frame |
|---|---|
| Proportion and OTU types in the gastrointestinal microbiota of HIV-1 seropositive patients compared to the general population | Baseline |
| Proportion and OTU types in the gastrointestinal microbiota of HIV-1 seropositive patients based on CD4, viral load, the Elite controller status, antiretroviral and antibiotic treatment and the existence of invasive bacterial infections. | Baseline |
| Proportion and OTU types in the gastrointestinal microbiota of HIV-1 seropositive patients based on inflammation parameters (IL-6, TNF-a, IP-10), CRPus, CD14 and integrity of the epithelial barrier (I-FABP). | Baseline |
| Transcriptomic analysis in the groups that present differences in the microbiota and analysis of lymphocyte populations Th17 and Treg. | Baseline |
Countries
France
Outcome results
None listed