Femoral and Epidural Block After Total Knee Arthroplasty

COMPARISON OF CONTINUOUS FEMORAL NERVE BLOCK AND PATIENT CONTROLLED EPIDURAL ANALGESIA AFTER TOTAL KNEE ARTHROPLASTY

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02115945

Enrollment

Registered

2014-04-16

Start date

2013-02-28

Completion date

2014-03-31

Last updated

2014-04-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Postoperative Pain, Chronic Postoperative Pain

Keywords

chronic postoperative pain, total knee arthroplasty, femoral block, We aimed to compare the effects of epidural and femoral block on acute and chronic postoperative pain.

Brief summary

Total knee prosthetic replacement causes severe postoperative pain. Various analgesic techniques have been used in pain control. Comparison of epidural and femoral nerve block is lacking, furthermore effect on chronic pain is unclear. The investigators aimed to compare the effects of epidural and femoral block on acute and chronic postoperative pain.

Detailed description

Background and aim Total knee prosthetic replacement causes severe postoperative pain. Various analgesic techniques have been used in pain control. Comparison of epidural and femoral nerve block is lacking, furthermore effect on chronic pain is unclear. The investigators aimed to compare the effects of epidural and femoral block on acute and chronic postoperative pain. Methods The study was of randomized, prospective, and double-blind design and was conducted with 80 patients who had undergone total knee prosthetic replacement surgery with the insertion of a femoral nerve block or epidural block catheter to initiate postoperative analgesia. One-sided spinal anesthesia was performed in all the patients. Postoperative pain control was achieved with the administration via catheter using bupivacaine for patient-controlled analgesia. Acute postoperative pain was evaluated in the first 24 hours and chronic postoperative pain in the 1st and 3rd months following surgery. The anxiety/depression scale was used to assess anxiety and depression, the SF 12 test was used to evaluate quality of life, and the DN4 test was employed at patient visits at the 1st and 3rd months.

Interventions

OTHERDN4 test

The DN4 test was used to evaluate neuropathic pain.

OTHERThe SF 12 test

The SF 12 test (SHORT FORM 12) was used to evaluate quality of life.

OTHERHAD scale

The anxiety/depression scale (HAD) was used to assess anxiety and depression.

OTHERVisual analogue score

Visual analogue score vas used to evaluate pain.

PROCEDUREfemoral block

PROCEDUREepidural block

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Clinical diagnosis of total knee arthroplasty

Exclusion criteria

* Patients with pain syndromes * Patients using routinely medications for pain

Design outcomes

Primary

Measure	Time frame
Persistent surgical pain after total knee arthroplasty assessed by VAS scale	3 months

Secondary

Measure	Time frame
The anxiety and depression was evaluated with Hospital anxiety and depression scale.	3 months

Other

Measure	Time frame
Quality of life was evaluated with SF 12 test.	3 months
Neuropathic pain was evaluated with DN4 test.	3 months.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026