Effect of Transcutaneous Nerve Stimulation on Primary Motor Cortex to Modulate Cortical Excitability and Hemodynamic Response During Implicit Motor Learning: A TMS and NIRS Study

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02115841

Enrollment

Registered

2014-04-16

Start date

2013-08-31

Completion date

2014-07-31

Last updated

2014-04-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Transcutaneous Nerve Stimulation

Keywords

Transcutaneous Nerve Stimulation, serial reaction time task, functional near infrared spectroscopy, transcranial magnetic stimulation

Brief summary

Noninvasive brain stimulation was recently gradually be emphasized. The electrical current applied on scalp can effective modulate cortical excitability. Forms of Stimulation included transcranial direct current stimulation(tDCS) and transcranial alternating stimulation(tACS). tDCS had been proved the effect of cortical excitability modulation. The polarization effect of direct current stimulation can modulation specific brain area and enhance motor performance. tACS was still controversial about the effect on cortical excitability. Previous study show that the frequency dependent excitatory or inhibitory effect on cortex. The possible mechanism was to affect brain oscillation status by provided different frequency of stimulation. Transcutaneous nerve stimulation (TENS) was common used on management of chronic pain. Peripheral nerve stimulation can enhance pain or sensory evoked potential was noted. Effect of low frequency TENS on central nervous is unknown.

Interventions

DEVICEEnraf-Nonius Muscle stimulator

The order 15Hz TENS stimulation session and sham stimulation session will also be randomized.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

20 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Health Adult

Design outcomes

Primary

Measure	Time frame	Description
Motor evoked potential	Baseline,0 minute,30 minutes,60 minutes.	Use single-pulse TMS to assess Motor evoked potential change.
Intracortical inhibition & Intracortical facilitation	Baseline,0 minute,30 minutes,60 minutes.	Use paired-pulse TMS to record pre-test and post-test change.
Blood oxygen dependent level	Baseline,in experiment,0 minute,30 minutes,60 minutes.	Use Near-infrared spectroscopy to record pre-test, in experiment, and post-test change
Implicit sequential motor task performance	Baseline,in experiment,0 minute,30 minutes,60 minutes.	Change of Measure of Learning curve.

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026