Motor Activity
Conditions
Keywords
Healthy volunteers, Physiological variables : respiration and circulation
Brief summary
This study is aimed to develop analysis methods and measurements tools for physiological variables : respiration, circulation and their mutual interactions and with the functions involved in the daily life in healthy volunteers (drinking, eating, sleeping, coughing...). The devices that are used are non invasive. The development of these tools needs to be validated on physiological signals obtained in healthy volunteers.
Detailed description
The analysis and interpretation of a record consist, for example, to measure the amplitude of the respiratory modulation of the cardiac period, a witness of the level of the subject's sympathetic activity. To do this, a mathematical model of this oscillation is adjusted on the experimental data, and its characteristics (amplitude, phase, non-linearity...) are considered indexes of the interaction to be compared with the same characteristics in other conditions. The transition to clinical applications requires validation of the developed tools on physiological signals recorded on healthy volunteers in a non-clinical environment, avoiding extra psychological stress in the Protocol followed. Whether it is for the development of tools or their validation, it is essential that the sensors used are non-invasive. Recorded situations are those of everyday life, such as working (only sedentary work are envisaged), eat, talk, rest and move from one place of life to another one.
Interventions
DEVICEa set of wearable respiration and cardiac monitoring devices
feasibility of methods for detecting physiological state changes from a set of wearable respiration and cardiac monitoring devices
Sponsors
Université Joseph Fourier
Centre National de la Recherche Scientifique, France
University Hospital, Grenoble
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* healthy, major and socially insured human subjects
Exclusion criteria
* deprived of liberty, hospitalized and protected human subjects
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Feasibility and use of developed methods and tools in clinical or fundamental research protocols or in systems for physiological monitoring in humans | up to 24 months | The new tools for identification and monitoring of the physiological state of a subject will be developed from a set of non-invasive measures at rest. Resulting physiological state identification will then be validated on registrations on the same subjects in different daily life circumstances. |
Countries
France
Outcome results
None listed