Cognitive Decline
Conditions
Keywords
Physical activity, Cognitive training
Brief summary
Investigators assume that there are some positive effects of cognitive training and physical activities on cognitive function, depression and quality of life in a sample of older residents in long-term care facilities. The purpose of this study is to explore the effects of various interventions (physical activity, cognitive training, integration of physical activity and cognitive training) on different outcome indictors in institutionalized older residents.
Detailed description
1. to develop an intervention protocol that achieves clinical development objectives in a scientifically rigorous and time efficient manner. 2. to further analyze the effects of the various interventions and make a comparison of dose-response relation and efficacy.
Interventions
BEHAVIORALPhysical Activity
group-based physical activity
BEHAVIORALCognitive Training
individual-based, multi-domains cognitive training
Sponsors
National Science and Technology Council, Taiwan
National Taiwan University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 65 year and older * Able to communicate verbally * Able to discern 5\*5 cm2 picture from a viewing distance of 20 cm * Able to hear a sound of normal speech from a distance of 20 cm * Able to sit in a chair or wheelchair independently for more than 30 minutes without changes in vital signs and awareness and without physical discomfort * Has cognitive decline status assessing by CASI 2.0 * Lived in long-term care facilities during the study
Exclusion criteria
* Complete aphasia, blindness, deafness or completely dependent * Unstable angina, arrythmia, myocardial infarction history, postural hypotension, transient cerebral hypoxia or other psychiatric disorders except depression * Thrombophlebitis, or malignancy of the limbs. * Refusal by patient or family member. * Others. Reason to be well documented.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline Cognitive Function at 8 weeks and 16weeks | pre-treatment (0 week, T0), post-treatment (8 weeks, T1) and follow-up (16 weeks, T2 ) | Cognitive Function: Cognitive Assessment Screening Instrument (CASI) 2.0 in Chinese version |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline Depression at 8 weeks and 16weeks | pre-treatment (0 week, T0), post-treatment (8 weeks, T1) and follow-up (16 weeks, T2 ) | Depression: Geriatric depression scale (GDS)-15 in Chinese version. |
| Change from Baseline Quality of Life at 8 weeks and 16weeksStatus: | pre-treatment (0 week, T0), post-treatment (8 weeks, T1) and follow-up (16 weeks, T2 ) | Quality of Life: Short Form-12 (SF-12) in Chinese version. |
Countries
Taiwan
Contacts
Primary ContactMeei-Fang Lou, PhD
Backup ContactChien-Ning Tseng, PhC
Outcome results
None listed