Effect of Betamethasone Gel and Lidocaine Jelly on Sore Throat, Cough and Hoarseness of

Effect of Betamethasone Gel and Lidocaine Jelly Applied Over Tracheal Tube Cuff on Post Operative Sore Throat, Cough and Hoarseness of Voice on the Patients

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02114021

Enrollment

Registered

2014-04-15

Start date

2012-03-31

Completion date

2013-03-31

Last updated

2014-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sore Throat, Cough

Keywords

Syndrome incidence after intubation, Betamethasone gel, lidocaine jelly, sore throat, cough, hoarseness of voice

Brief summary

ABSTRACT: The aim of this study was to investigate the effect of betamethasone gel and lidocaine jelly (over tracheal tube cuff) compared with distilled water on the post intubation syndrome incidence. This study has not been carried out in Iran. 99 patients of either sex undergoing elective surgery were recruited in a single blind randomized study. The patients, using randomization table, were divided into three groups. Anesthetics and medications used during surgery were similar for all the patients. For the all patients, the incidence of postoperative sore throat, cough and hoarseness of the voice in the different follow-up periods (1, 6 and 24 hours) based on the different types of medications were obtained.

Interventions

DRUGbetamethasone gel

betamethasone gel (over tracheal tube cuff) compared with distilled water on the post intubation syndrome incidence.

DRUGlidocaine jelly

the effect of lidocaine jelly (over tracheal tube cuff) compared with distilled water on the post intubation syndrome incidence.

DRUGdistilled water

The effect of betamethasone gel and lidocaine jelly (over tracheal tube cuff) compared with distilled water on the post intubation syndrome incidence.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Caregiver)

Eligibility

Sex/Gender

ALL

Age

15 Years to 50 Years

Healthy volunteers

Inclusion criteria

1. 50 years\<age\>15 years 2. no acute upper respiratory infections and no sore throat 3. candidate for elective surgery unrelated to the throat 4. The lack of airways difficulties 5. candidate for general anesthesia with intubation 6. no contraindications for receiving steroid 7. surgery time \< 240 minutes 8. intubation up to 2 times 9. tracheal tube cuff pressure = 25-30 cm H2o 10. fasting for 8-6 hours prior to surgery 11. ASA I and ASAII and 12. Surgery under general anesthesia and endotracheal intubation

Exclusion criteria

1. use of nasogastric tube or throat packs 2. patients with upper respiratory tract infection 3. patients on steroid therapy were excluded from the study

Design outcomes

Primary

Measure	Time frame	Description
sore throat	24 hours after surgery	For the all the patients, the incidence of postoperative cough in 24 hours follow-up based on the different types of medications were obtained (using questionnaire).
cough	1 hour after surgery	For the all the patients, the incidence of postoperative cough in 1 hour follow-up periods based on the different types of medications were obtained (using questionnaire).
hoarseness of voice	1 hour after surgery	For the all patients, the incidence of postoperative hoarseness of the voice in 1 hour follow-up period based on the different types of medications were obtained (using questionnaire).

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026