Contrast Induced Nephropathy
Conditions
Keywords
coronary angiography, chronic stable angina, CIN
Brief summary
As the effect of statin use before the angiography to prevent contrast induced nephropathy (CIN) is not well-known, the aim of the current study is to assess the effect of atorvastatin on prevention of CIN in patients undergoing coronary angiography.
Interventions
DRUGAtorvastatin
Sponsors
Isfahan University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Inclusion criteria
* having chronic stable angina who were referred for coronary angiography * non-pregnant female subjects * no history of diabetes mellitus * no history of renal failure * no history of single kidney * no history of cardiogenic shock * no history of unstable angina * no history of myocardial infarction * no history of hypersensitivity to statins * no history of previous intravascular contrast injection during one month before admission
Exclusion criteria
* glomerular filtration rate (GFR) \<60 * cardiogenic shock
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Contrast induced nephropathy (CIN) incidence | 48 hours after the procedure | CIN is determined as an increase in post-procedural serum creatinine of \> 0.5 mg/dl or \> 25% from baseline in the absence of any other causes |
Secondary
| Measure | Time frame |
|---|---|
| serum creatinine (Cr) level | 48 hours after the procedure |
Countries
Iran
Outcome results
None listed