Bladder Cancer
Conditions
Keywords
HGT1, high risk bladder cancer, substaging, repeat transurethral resection (reTUR), lamina propria
Brief summary
Non-muscle invasive bladder cancer of High Grade stage T1 (HGT1), has up to 20% risk of progression to invasive disease. Because the depth of substaging seems to identify two separate groups with different progression risk (HighGradeT1a and HighGradeT1b), we design a differential treatment strategy for each group. The main hypothesis is that HighGradeT1a bladder cancer can spare a second endoscopic procedure.
Detailed description
Only cases of initial diagnosis of HighGradeT1 and with a complete transurethral endoscopic resection (TUR) of bladder tumor) can enter this protocol. HighGradeT1a will only receive standard BCG treatment (induction and maintenance). HighGradeT1b will undergo a second transurethral endoscopic resection (TUR) after the induction of Bacillus de Calmette-Guerin (BCG) and then continue mantenaince BCG and standard follow-up.
Interventions
None listed
Sponsors
Hospital Universitari Vall d'Hebron Research Institute
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* HGT1 bladder cancer at initial diagnosis and after a complete TUR
Exclusion criteria
* abscence of muscularis propria in the TUR specimen
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| progression | 5year |
Secondary
| Measure | Time frame |
|---|---|
| recurrence | 5year |
Other
| Measure | Time frame |
|---|---|
| Cancer specific survival | 5year |
Countries
Spain
Outcome results
None listed