Energy Metabolism in Patients With Short Bowel Syndrome

Assessment of Energy Metabolism in Patients With Short Bowel Syndrome Using the Doubly Labeled Water Method

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02113228

Enrollment

Registered

2014-04-14

Start date

2013-03-31

Completion date

2014-12-31

Last updated

2014-12-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Short Bowel Syndrome

Keywords

Energy metabolism, Stable isotopes, Short bowel syndrome, Doubly labeled water

Brief summary

This study proposes to verify the total energy expenditure in patients with short bowel syndrome using the doubly labeled water method, as well as determining the rate of oxidation of nutrients, aiming to assist the management of nutritional therapy for these patients.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Short bowel syndrome: short bowel syndrome patients with gastrointestinal transit time less or equal 30 minutes. * Control group: patients with the same gender, presenting age and chronic diseases similar with volunteers from the group with short bowel syndrome.

Exclusion criteria

\- Short bowel syndrome: time of bowel resection surgery less than 1 year.

Design outcomes

Primary

Measure	Time frame	Description
Assessment of total energy expenditure using the doubly labeled water method	14 days	After the determination of resting energy expenditure (REE), each volunteer will receive a dose of doubly labeled water (2H2 18O). A basal urine sample is collected before the intake dose and samples taken on days 1, 2, 3, 7, 12, 13, 14, thereafter. Urine samples will be analyzed by mass spectrometry (Hydra System, HIP 20-20, Europa Scientific, Cheshire, UK) in the Mass Spectrometry Laboratory of the Faculty of Medicine of Ribeirão Preto.

Secondary

Measure	Time frame	Description
Resting energy expenditure (REE) and body composition measurements by indirect calorimetry and electrical bioimpedance, respectively.	After 12 hours of overnight fasting	This study also aims to measure the REE by indirect calorimetry with a Quark (Cosmed, Italy) calorimeter and the body composition by Byodinamics 450 (Biodynamics Corp., United States).
Physical activity assessment	14 days	An activity monitor (activPAL ®, Glasgow, UK) is used to determine physical activity. By registering the intensity and duration of each category of activities, the system adds the energy estimated to generate a value that reflects the total energy expenditure.

Countries

Brazil

Outcome results