Coronary Artery Disease
Conditions
Keywords
troponin t,cystatin-c,ketamine,remifentanil
Brief summary
In this prospective, randomized, clinical trial, we have investigated the effects of ketamine-based and remifentanil-based anesthetic protocol on perioperative serum cystatin-c levels, and creatinine and/or cystatin-c based eGFR equations in terms of acute kidney injury in CABG surgery.This study was approved by the Ethics Committee of Hospital and all patients were informed and gave written consent. Patients scheduled for elective CABG with cardiopulmonary bypass. Patients were randomly allocated to anesthesia with remifentanil-propofol-midazolam (RPM) group or ketamine-propofol-midazolam (KPM) group. Blood samples were obtained before induction of anesthesia (baseline), at the end of the operation, and postoperative days 1, 2, and 4.
Interventions
DRUGremifentanil
renal function
DRUGKetamine
renal function
Sponsors
Turkiye Yuksek Ihtisas Education and Research Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
patients undergoing elective CABG with cardiopulmonary bypass
Exclusion criteria
patients undergoing emergency operation, combined operation, off-pump surgery, repeat surgery or valve surgery, patients presenting with chronic kidney disease or renal impairment, patients younger than 18 years old and neurological and/or psychiatric disturbances.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| creatinin, BUN | 2 months |
Secondary
| Measure | Time frame |
|---|---|
| Cystatin-c level | 2 months |
Other
| Measure | Time frame |
|---|---|
| GFR value | 2 months |
Countries
Turkey (Türkiye)
Outcome results
None listed