Focus Chronic Kidney Disease With Hypertension
Conditions
Keywords
Exercise, blood pressure, chronic kidney disease
Brief summary
The general objective of the study is to investigate the effect of regular aerobic exercise on resting and 24-hr blood pressure levels in men and women with stage 3-4 kidney disease and hypertension.
Interventions
BEHAVIORALExercise
Blended supervised-home based walking exercise 3-4 times per week for 30-45 minutes
Sponsors
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
University of Minnesota
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* • Non-diabetic and \>18 years of age * Diagnosed kidney disease with associated hypertension: * Non-nephrotic range proteinuria at diagnosis * No active glomerular disease or concomitant systemic inflammatory disease (e.g. lupus) * Systolic blood pressure \>130 and/or diastolic blood pressure \>80 mm Hg (on medication) * An estimated glomerular filtration rate of between 60 ml/min and 15 ml/min. * Individuals must be able to provide informed consent * Perform walking exercise training on a treadmill * Be able to participate in a 12-week supervised exercise program.
Exclusion criteria
* Currently participating in a formal exercise program * Diabetes, active glomerular disease, or systemic inflammatory disease * Requiring dialysis * Have an Hematocrit \<27% * Uncontrolled hypertension (\>200/110mmHg) * Peripheral vascular disease. * An inability to understand English or give consent. Other
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| blood pressure | at week 0 and at week 12 | resting and 24-hour ambulatory blood pressure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| effective vascular compliance | at week 0 and at week 12 | Pulse wave velocity estimated systemic vascular resistance |
| endothelial function | at week 0 and at week 12 | measured by brachial artery flow mediated vasodilation |
| biomarkers associated with blood pressure | at week 0 and at week 12 | Circulating levels of angiotensin 2 Circulating levels of endothelin 1 asymmetric dimethylarginine |
Countries
United States
Outcome results
None listed