Sports Nutritional Sciences
Conditions
Keywords
endurance sportswomen, addiction, undernutrition, [11C]diprenorphine Pet, pituitary region
Brief summary
Abnormal opioid system have been identified in addictive behavior and activity of the opioid system has also shown a strong link with the nutritional balance. A significant increase in endorphin levels was noticed after exercise, proportional to the duration and intensity of this activity. One brain imaging study showed an increase in opioid activity in athletes after endurance training. However , a decrease in opioid tone related to receptor desensitization in the brain has been raised in the sport and it is possible to feel like , the subject must perform physical exercise more frequently . Consequently, in order to deepen the hypothesis of addiction in high-level sport , the brain opioid activity should be assessed pre- training compared to a group of sedentary control subjects . Preliminary results of a previous study the investigators are conducting on anorexia nervosa (AN ) show abnormalities that appear to be involved in self addiction anorexia nervosa and the regulation of gonadal function. However, the relation of cause and effect between these anomalies and undernutrition remains to be determined . Given the addictive component in the endurance sport and the variability of the nutritional status of its practitioners , evaluation of brain activity in these subjects could provide additional answers.
Interventions
OTHER[11C]diprenorphine
3 micrograms \[11C\]diprenorphine - intravenous use - 1 time
Sponsors
Ministry of Health, France
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
For High-level sportswomen : * 18-35-year-old * High-level sportswomen * BMI\>19kg/m2 * Absence of eating disorders * In pre-competition period * Signature of written consent For controls : * 18-35-year-old * Sedentary normal weight women * BMI\>19kg/m2 * Normal nutritional markers * Absence of eating disorders or other psychiatric or organic diseases
Exclusion criteria
* Oral contraception * Heart failure * Neuroleptics, antiparkinson drugs, alpha-methyl-dopa, beta blockers, inhibitors of monoamine oxidase-A or MOA-B, tricyclic antidepressants, selective serotonin reuptake inhibitor, thyme-regulators (lithium), anticonvulsant drugs, codeine, morphine, drugs containing tramadol, dopaminergic drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| [11C]diprenorphine binding potential | 2 weeks | Value of \[11C\]diprenorphin binding potential in predifined brains regions. \[11C\]diprenorphin BP will be evaluated by brain positron emission tomography and MRI exam |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| correlation [11C]diprenorphine BP | 2 weeks | Correlation between \[11C\]Diprenorphine binding potential and plasma endogenous opioid levels |
Countries
France
Outcome results
None listed