Acute Severe Asthma
Conditions
Keywords
Magnesium sulphate nebulized
Brief summary
The purpose of this study is to determine whether nebulized magnesium sulphate is effective in the treatment of acute severe asthma when comparison with intravenous magnesium sulphate
Detailed description
Intervention: At randomization eligible patients were allocated to receive 2.5ml of isotonic magnesium sulphate (150 mg,245 mmol/L) on three occasional at 20 minutes interval or standard treatment 50 mg/kg intravenous magnesium sulphate. The asthma severity score was record at 0,20,40,60,120,180,240 minutes post randomization. Adverse event were assessed at each assessment point. Patients were followed up until discharge from hospital to collect secondary outcome data.
Interventions
DRUGisotonic magnesium sulphate
2.5 ml of isotonic magnesium sulphate (150 mg, 245 mmol/L) NB on three occasional at 20 minutes interval
DRUG50% magnesium sulphate
magnesium sulphate 50mg/kg/dose intravenous drip in 20 minutes for one dose
Sponsors
Queen Sirikit National Institute of Child Health
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
2 Years to 15 Years
Healthy volunteers
No
Inclusion criteria
* Children age 2-15 years presenting with severe asthma or persistent wheeze without responding to conventional therapy
Exclusion criteria
* chronic lung disease * history of adverse reaction form magnesium sulphate * life threatening condition
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Asthma severity score | 60 minute |
Secondary
| Measure | Time frame |
|---|---|
| Length of stay in the hospital | within 2 weeks |
Countries
Thailand
Outcome results
None listed