Acute Hypercapnic Respiratory Failure
Conditions
Keywords
ICU, COPD, OHS, OSA, heart failure
Brief summary
There is currently no good description of patients surviving an episode of acute hypercapnic respiratory failure in the ICU. For instance, the prevalence of OSA and sleep hypoventilation in a stable clinical condition is not known in this population. This prospective cohort describes the clinical profile, predictors of readmission (followed over a year), and the prevalence of sleep-related breathing disorders (polysomnography in a stable clinical condition 3 months after ICU discharge) in patients treated for an episode of acute hypercapnic respiratory failure in the ICU.
Interventions
None listed
Sponsors
University Hospital, Geneva
Ligue Pulmonaire Genevoise
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \> 18 years Informed consent surviving an episode of acute hypercapnic respiratory failure
Exclusion criteria
* iatrogenic hypercpania pregnant woman
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sleep apnea syndrome | at 2 month after ICU discharge | Apnea-Hypopnea Index defined by polysomnography |
| Sleep Hypoventilation | at 2 month after ICU discharge | defined by AASM 2012 criteria with transcutaneous PtCO2 monitoring |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lung physiology ( obstructive or restrictive lung disease) | at week 2 after ICU discharge | FEV1, VC, TLC, DLCO |
| Inspiratory Muscle Strength | at week 2 after ICU discharge | Sniff nasal maximal inspiratory pressure, Mouth inspiratory pressure |
| Cardiac function | at week 2 after ICU discharge | Systolic and diastolic cardiac function, pulmonary hypertension |
| Hospital and ICU readmission rate | 1 year follow-up after ICu discharge | — |
Countries
Switzerland
Outcome results
None listed