Is High Sensibility Troponins a Dialysable Marker in Hemodialysis Patients and Does it Have Prognostic Value?

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02111733

Acronym

TnT-HD

Enrollment

Registered

2014-04-11

Start date

2013-06-30

Completion date

2013-09-30

Last updated

2014-04-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal Failure

Brief summary

Evaluation of High sensibility troponin levels modification by hemodialysis in terminal renal failure patient at Sherbrooke University Hospital Center as determined by serial measurements. Verification of potential effects of these levels and their variation as predictors of cardiovascular outcomes and events at 6 and 12 months.

Detailed description

Recruiting of hemodialysis patients of the nephrology renal supplementation clinics at Sherbrooke University Hospital Center to measure three blood level of high-sensibility troponins before and after standard dialysis. Verification on the variation of these levels after dialysis. Follow-up at 6 and 12 months of the patient for Cardiovascular events and death and verification of a possible predictive value of troponin blood levels for these events.

Interventions

OTHERHs-TNT dosage

Bloodwork before and after hemodialysis for high sensibility troponins T blood level

Study design

Allocation

Intervention model

SINGLE_GROUP

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Inclusion criteria

* over 50 years, no symptoms, over 1 months of hemodialysis

Exclusion criteria

* 1 or more in the last month; Acute coronary syndrome, Heart failure decompensated, Myo or Pericarditis, Pulmonary embolism, Sepsis/shock, Stroke or transient ischemic attack, Malignant high blood pressure, Arrythmia, electrical cardio-version, major trauma, significant burnings (\>25%), Chemotherapy, Cardiovascular surgery, percutaneous angio-intervention, * Chronic systemic disease (sarcoidosis, amyloidosis, LED, Etc.)

Design outcomes

Primary

Measure	Time frame	Description
High sensibility troponins T blood level variation	1 week	Verification of high sensibility troponins T blood after classical hemodialysis compared to pre-treatment levels.

Secondary

Measure	Time frame	Description
Prognostic value of high sensibility troponins T blood level variation	at 6 and 12 months	Evaluation of a potential prognosis value of high sensibility troponins T blood levels and its variation after hemodialysis.

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026