Porphyromonas Gingivalis and Alzheimer's Disease

Porphyromonas Gingivalis - a Responsible Pathogen in Alzheimer's Disease?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02109705

Acronym

PGNEURO

Enrollment

Registered

2014-04-10

Start date

2014-03-31

Completion date

2021-01-31

Last updated

2023-05-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer's Disease, Dementia, Periodontitis

Brief summary

With this study the investigators would like to analyze the the role of periodontal disease and especially the role of Porphyromonas gingivalis in initiation and progression of Alzheimer's Disease.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* age 40-70 * caucasian origin * dementia (Alzheimer's or other dementia) * cognitive healthy (need for spinal anesthesia)

Exclusion criteria

* use of antibiotics within las 6 months * pregnancy * another illness explaining the symptoms in a better way * smoking (\>10 cigarettes) * patients who have a legal custodian

Design outcomes

Primary

Measure	Time frame	Description
Cmax Antibody Levels against Gingipains	Baseline	laboratory analysis

Secondary

Measure	Time frame	Description
Cmax Beta-Amyloid	Baseline	laboratory analysis

Other

Measure	Time frame	Description
Cmax: Periodontal pathogens	Baseline	laboratory analysis
U enzyme activities	Baseline	laboratory analysis
Cmax: inflammatory cytokines	Baseline	laboratory analysis

Countries

Germany

Outcome results