Corneal Opacities (Scar and Stromal Dystrophy)
Conditions
Keywords
corneal opacities, Optical coherence tomography
Brief summary
A prospective observational study on corneal opacities (scar and stromal dystrophy) in adults (n=150) will be conducted at OHSU. The Optovue anterior segment OCT will be used to perform 3-D corneal scans. These scans will be used to assess opacity depth and measure corneal thickness (pachymetry), corneal topography (anterior and posterior), and epithelial thickness maps. The ultrahigh-speed MIT OCT prototypes will also be used when they become available. A comprehensive eye examination, Placido-ring corneal topography, ultrasound pachymetry, and Scheimpflug camera imaging, will be performed for comparison.
Interventions
None listed
Sponsors
National Eye Institute (NEI)
Oregon Health and Science University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
• Adult (18 & older) patients presenting in OHSU Casey Eye Clinic with corneal opacities (scar and stromal dystrophy)
Exclusion criteria
* Inability to give informed consent. * Inability to maintain stable fixation for OCT imaging. * Inability to commit to required visits to complete the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Identification of suitable subjects | 2 years | The primary goal of this observational study is to identify suitable subjects for the clinical trials of OCT-guided transepithelial PTK. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Validate OCT topography | 2 years | A second goal is to validate OCT anterior topography by comparison with standard Placido-ring corneal topography and develop a mathematical model that relates epithelial thickness variation to corneal mean curvature. |
Countries
United States
Contacts
Primary ContactHumberto Martinez, COT
Backup ContactDenzil Romfh, OD
Outcome results
None listed