Disuse Atrophy
Conditions
Brief summary
In the present study, the effects of 7 days of bed rest on muscle mass, muscle fiber characteristics and insulin sensitivity will be determined.
Interventions
BEHAVIORALBed rest
Sponsors
Maastricht University Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Male * Aged from 18-35 years * 18.5 \< BMI \< 30 kg/m2
Exclusion criteria
* Smoking * Performing regular resistance training (3+ times per week, carrying out progressive training) in the previous 6 months * Hypertension (according to WHO criteria) and/or cardiovascular disease * Any back/leg/knee/neck/postural complaints * Use of any prescribed medication * Type 2 diabetes mellitus * Any family history of thrombosis * All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis). * Myocardial infarction within the last 3 years * Use of anti-coagulants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in quadriceps muscle cross-sectional area | One day before and directly after cessation of bed rest. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in lower back cross-sectional area | One day before and directly after cessation of bed rest. | — |
| Change in leg and whole body lean tissue mass | One day before and directly after cessation of bed rest. | — |
| Change in muscle fiber size | One day before and directly after cessation of bed rest. | — |
| Change in muscle strength | One day before and directly after cessation of bed rest. | Measured by 1-Repetition Maximum testing |
| Change in insulin sensitivity | One day before and directly after cessation of bed rest. | Measured by hyperinsulinemic-euglycemic clamp |
Countries
Netherlands
Outcome results
None listed