MMP-9 Monitoring Particulate Cerebral Embolisation

Dynamic Changes of MMP9 Concentration Cross Carotid Endarterectomy Monitoring Particulate Cerebral Embolisation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02109120

Acronym

MMP9MPCE

Enrollment

Registered

2014-04-09

Start date

2012-02-29

Completion date

2013-11-30

Last updated

2014-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral Embolic Damage

Brief summary

1. In carotid endarterectomy(CEA) surgery, the dynamic changes of plasma MMP9 concentration cross CEA will be identified. 2. And the part of patients suffered particulate cerebral embolic injury, their MMP9 level will increase in the early stage after CEA.

Interventions

PROCEDUREvein blood collection

5 ml peripheral vein blood samples were collected from each patient admitted to our study at the following time-points：Pre-operative（morning of surgery），just before declamping，30mins after declamping and post-operative（12h）.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 90 Years

Healthy volunteers

Inclusion criteria

-All patients enrolled had at least ≥70% unilateral or bilateral stenosis of Internal -Carotid Artery， or those who had a \<70% stenosis but obvious cerebral ischema symptoms had been existed.

Exclusion criteria

Design outcomes

Primary

Measure	Time frame
postoperative ischemic stroke	7 days after surgery

Secondary

Measure	Time frame
postoperative elevation of plasma MMP9	perioperative phage

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026