Towards Individualized Surgery in Non-focal Congenital Hyperinsulinism

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02108730

Acronym

non-focal CHI

Enrollment

Registered

2014-04-09

Start date

2011-03-31

Completion date

2014-03-31

Last updated

2014-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-focal Congenital Hyperinsulinism

Brief summary

Observational study in patients with non-focal congenital hyperinsulinism showing that restrictive surgery may improve the metabolic situation

Detailed description

In non-focal congenital hyperinsulinism (CHI) the current doctrine warrants subtotal pancreatic resection in all children who do not respond to medication. However, the rate of diabetes after these extensive resections is very high. In this study investigators show that a less aggressive approach may suffice to wean many children from all medication or to get them manageable medically.

Interventions

PROCEDURErestrictive pancreatic resection

Restrictive, spleen-preserving resection of the pancreatic tail by laparoscopy

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* patients with non-focal congenital hyperinsulinism

Exclusion criteria

* patients with focal congenital hyperinsulinism

Design outcomes

Primary

Measure	Time frame
necessity of medication after restrictive surgery in congenital hyperinsulinism	up to 3 years

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026