Optical Coherence Tomography in Staging Patients With Upper Tract Urothelial Cancer

Staging of Upper Tract Urothelial Cancer With Optical Coherence Tomography

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02108587

Enrollment

Registered

2014-04-09

Start date

2016-12-31

Completion date

Unknown

Last updated

2016-10-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney/Urinary Cancer

Brief summary

This clinical trial studies how well optical coherence tomography works in staging patients with upper-tract urothelial carcinomas. Staging describes the severity of a person's cancer based on the size and/or extent (reach) of the original (primary) tumor and whether or not cancer has spread in the body. It also helps the doctor plan the appropriate treatment. Optical coherence tomography is a procedure that uses infrared light waves to give three-dimensional pictures of structures inside tissues and organs. The pictures are made by a computer linked to the light source. Optical coherence tomography may be effective in staging patients with upper-tract urothelial carcinomas.

Detailed description

PRIMARY OBJECTIVES: I. To test the feasibility and imaging ability of optical coherence tomography (OCT) to stage upper-tract urothelial carcinomas (UTUC). OUTLINE: Patients undergo optical coherence tomography over 10-15 minutes. After completion of study, patients are followed up at 3 months.

Interventions

DEVICEoptical coherence tomography

Undergo optical coherence tomography

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients must have radiographic evidence of upper tract urothelial cancer by computed tomography (CT), magnetic resonance imaging (MRI) or intravenous pyelogram (IVP) in order to undergo this procedure * Patient who will undergo standard of care clinical staging for UTUC * Patient ability to read and comprehend the informed consent document

Exclusion criteria

* Patient who has a contraindication to endoscopy * Patient who is pregnant

Design outcomes

Primary

Measure	Time frame	Description
Feasibility of optical coherence tomography (OCT) images in staging upper-tract urothelial carcinomas (UTUC)	Up to 3 months	Feasibility defined as the ability to relate the features associated with cancerous tissues in pathohistological analysis to the features in OCT images

Secondary

Measure	Time frame	Description
Imaging Analysis	Up to 3 months	Number of cancerous images with at least one feature different from normal pathology slide

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026