The Importance of Needle Gauge for Pain During Injection of Local Anaesthetic

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02107729

Enrollment

Registered

2014-04-08

Start date

2014-02-28

Completion date

2014-06-30

Last updated

2016-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Needlestick Injuries

Keywords

Injections, Pain, Healthy volunteers, Lidocaine

Brief summary

This study will investigate the influence of needle gauge on pain during injection of local anaesthetic. Healthy volunteers will be recruited, who will each receive three injections with either 21G, 23G or 27G subcutaneously on the abdomen. After each injection, the participants will be asked to evaluate the pain on a Visual analog scale (0-100 mm). It is anticipated that the pain will decrease with decreasing thickness of the needle. The aim of this study is to find a simple method for pain reduction that can be used in clinical practice.

Interventions

PROCEDURELarge needle gauge lidocaine injection

21 G

PROCEDURENormal needle gauge lidocaine injection

23 G

PROCEDURESmall needle gauge lidocaine injection

27 G

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Age 18-65 years

Exclusion criteria

* Kidney, heart or liver disease * Eczema or psoriasis on injection site * Neuropathy * Regular use of painkillers * Hypersensitivity of Lidocaine * Pregnancy * Diabetes

Design outcomes

Primary

Measure	Time frame	Description
Pain	60 seconds	1. Visual analog scale 2. Questionnaire

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026