Will Adjusting the pH of Lidocaine Reduce the Pain During Injection of Local Anaesthetic?

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02107716

Enrollment

Registered

2014-04-08

Start date

2014-02-28

Completion date

2014-06-30

Last updated

2015-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Needlestick Injuries

Keywords

Pain, Injections, Lidocaine, Healthy volunteers

Brief summary

This study will investigate the influence of adjusting the pH of lidocaine on pain during subcutaneous injection. Each participant will receive two injections on the abdomen with different pH. After each injection, the subject will be asked to evaluate the pain on a Visual analog scale (0-100 mm). It is anticipated that the pain decreases with increasing pH. The aim of the study is to find a simple method for pain reduction that can be used in clinical practice.

Interventions

PROCEDURELidocaine injection with bicarbonate

bicarbonate added to change pH

PROCEDURElidocaine injection

Lidocaine injection with pH unchanged

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

fyll inn * Age 18-65 years

Exclusion criteria

* Kidney, heart or liver disease * Eczema or psoriasis on injection site * Neuropathy * Regular use of painkillers * Hypersensitivity of Lidocaine * Pregnancy * Diabetes

Design outcomes

Primary

Measure	Time frame	Description
Pain	60 seconds	1. Visual Analog Scale 0-100 mm 2. Questionnaire

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026