The Influence of Lidocaine Temperature on Pain During Subcutaneous Administration

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02107690

Enrollment

Registered

2014-04-08

Start date

2014-02-28

Completion date

2014-06-30

Last updated

2016-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Needlestick Injuries

Keywords

Injections, Temperature, Pain, Healthy volunteers, Lidocaine

Brief summary

This study will investigate the influence of lidocaine temperature on pain during injection of lidocaine. Each participant will receive three injections subcutaneously on the abdomen with different temperatures. After each injection, participants will be asked to evaluate the pain on a Visual analog scale (0-100 mm). It is anticipated that the pain decreases with increasing temperature. The aim of the study is to find a simple method for pain reduction that can be used in clinical practice.

Interventions

PROCEDURELow temperature lidocaine injection

4 °C

PROCEDURERoom temperature lidocaine injection

20 °C

PROCEDUREBody temperature lidocaine injection

37 °C

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Age 18-65 years

Exclusion criteria

* Kidney, heart or liver disease * Eczema or psoriasis on injection site * Neuropathy * Regular use of painkillers * Hypersensitivity of Lidocaine * Pregnancy * Diabetes

Design outcomes

Primary

Measure	Time frame	Description
pain	60 seconds	(1) visual analog scale 0-100mm, (2) questionnaire

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026