Hodgkin Lymphoma Survivor
Conditions
Keywords
MRI, stress echo, Clinical Assessment, 14-017
Brief summary
This study will test whether cardiac MRI can improve early detection of Hodgkin lymphoma associated heart disease compared to a stress echocardiogram. By doing both stress echocardiography and cardiac MRI, we will compare the ability of the two tests to detect heart disease.
Interventions
OTHERClinical Assessment
HL treatment will be determined by review of available medical records as archived at MSKCC. Recorded variables will include: (1) RT - field, fractional and cumulative dose, and duration; (2) chemotherapy - regimen, planned interval, dose per cycle, and cumulative dosages. Patients will also be asked to complete the FACT-LYM questionnaire and the FACIT Fatigue questionnaire.
PROCEDUREStress cardiac MRI
Both imaging tests will be performed within a 30 day interval, with the two modalities interpreted by dedicated study investigators blinded to the results of the other modality.
PROCEDUREStress echocardiogram
Both imaging tests will be performed within a 30 day interval, with the two modalities interpreted by dedicated study investigators blinded to the results of the other modality.
Sponsors
Memorial Sloan Kettering Cancer Center
Weill Medical College of Cornell University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Classical or nodular lymphocyte predominant HL treated at Memorial Sloan-Kettering Cancer Center. * Age ≥ 18 years * Treatment for HL that included mediastinal RT at initial diagnosis or relapse. * ≥ 5 years from last HL treatment.
Exclusion criteria
* Primary HL diagnosis prior to 1980. * Additional mediastinal RT or subsequent cardiotoxic systemic therapy for secondary malignant neoplasm. * Known CAD/CHF (defined as documented myocardial infarction, cardiac revascularization, angiographic obstructive CAD, or decreased LV function \[EF \< 55%\] during prior clinical care). * Contraindication to MRI (i.e. pacemakers, defibrillators, or aneurysm clips, or other implanted ferromagnetic objects), gadolinium (i.e. known hypersensitivity to gadolinium, advanced renal insufficiency as defined by glomerular filtration rate \<30 ml/min/1.73m\^2). * Contraindication to exercise stress testing other than the above (i.e. unstable angina or severe valvular stenosis).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| compare the prevalence of cardiac injury | 2 years | detected by cardiac MRI to that detected by stress echocardiography among a broadly representative cohort of Hodgkin lymphoma survivors. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORAlison Moskowitz, MD
Memorial Sloan Kettering Cancer Center
Outcome results
None listed