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Aerobic Exercise on Ventilatory Efficiency in CAD Patients

Effect of Aerobic Exercise Training on Ventilatory Efficiency in Patients With Coronary Artery Disease

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02106533
Enrollment
123
Registered
2014-04-08
Start date
2011-08-31
Completion date
2013-05-31
Last updated
2014-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complication, Cardio-respiratory, Coronary Artery Disease, Exercise Addiction

Keywords

Coronary artery disease, Exercise, Ventilatory efficiency

Brief summary

The purpose of the present study was to test the hypothesis that patients with coronary artery disease with lower aerobic fitness exhibit greater responsiveness on improving ventilatory efficiency after aerobic exercise training.

Detailed description

Measurements of ventilatory efficiency during cardiorespiratory exercise testing typically expressed as the minute ventilation/ carbon dioxide production ratio have been validated to be useful in assessing the presence and severity of both heart and lung diseases. In this context, previous studies have showed ventilatory inefficiency in patients with coronary artery disease suggests abnormalities in the distribution of ventilation and perfusion in the lungs. In addition, a growing body of studies has demonstrated that lower ventilatory efficiency during exercise is considered an important predictor of risk mortality, hospitalization, and other outcomes than peak VO2.

Interventions

OTHERAerobic exercise training

The exercise training program was comprised of three 60-minute exercise sessions per week over a 3-month period. Each exercise session consisted of a 5 minute warm up, 30-50 minutes of aerobic exercise performed on a treadmill and 5 minutes of cool-down exercises. Aerobic exercise intensity was set at the corresponding heart rate between the VAT and RCP. All patients were able to achieve the set aerobic training intensity.

Sponsors

Hospital TotalCor
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
48 Years to 77 Years
Healthy volunteers
No

Inclusion criteria

* was stable coronary artery disease diagnosed by coronary angiography

Exclusion criteria

* unstable angina pectoris, * complex ventricular arrhythmias, * pulmonary congestion and * orthopaedic or neurological limitations to exercise

Design outcomes

Primary

MeasureTime frameDescription
Ventilatory efficiency in patients with coronary artery diseaseup to 3 months of the interventionsMeasurements of ventilatory efficiency during cardiopulmonary exercise testing typically expressed as the minute ventilation/ carbon dioxide production ratio have been validated to be useful in assessing the presence and severity of both heart and lung diseases. In this context, previous studies have showed ventilatory inefficiency in patients with coronary artery disease suggests abnormalities in the distribution of ventilation and perfusion in the lungs.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 18, 2026