Repetitive Transcranial Magnetic Stimulation (rTMS) as an add-on Treatment for Resistant Obsessive-compulsive Symptoms in Patients With Schizophrenia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02105064

Enrollment

Registered

2014-04-07

Start date

2011-07-31

Completion date

2016-02-29

Last updated

2016-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive-Compulsive Symptoms, Schizophrenia

Brief summary

This is a study to evaluate the efficacy of rTMS for relief of obsessive-compulsive symptoms in patients with schizophrenia.

Interventions

DEVICEActive rTMS

rTMS over supplementary motor area, 1hz, no pauses, 20 minutes/sessions, 5 sessions/week, 4 weeks. Total 20 sessions.

DEVICESHAM rTMS

Sham rTMS, without brain stimulation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Diagnosis of Schizophrenia (DSM-IV-TR) * YBOCS ≥ 16

Exclusion criteria

* Mental Retardation * Substance abuse * Any contraindication to rTMS

Design outcomes

Primary

Measure	Time frame
Change of Obsessive Compulsive symptoms (using Yale-Brown Obsessive Compulsive Scale - Y-BOCS)	Baseline, after 20 rTMS sessions (an expected average of 4 weeks), and 4 weeks after end of treatment

Secondary

Measure	Time frame
Change of Psychotic Symptoms (using Brief Psychiatric Rating Scale - BPRS)	Baseline, after 20 rTMS sessions (an expected average of 4 weeks), and 4 weeks after end of treatment
Change of Brain-Derived Neurotrophic Factor (BDNF)	Baseline, after 20 rTMS sessions (an expected average of 4 weeks), and 4 weeks after end of treatment

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026