Study of Skin Parameters in the PROOF Cohort

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02104960

Acronym

PEAU PROOF

Enrollment

209

Registered

2014-04-07

Start date

2013-03-31

Completion date

2014-12-31

Last updated

2015-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skin Aging

Keywords

Skin Surface Microscopy, Skin Aging, PROOF

Brief summary

This study aims to evaluate skin aging of an homogeneous population of 77 years old patient selected among the PROOF cohort who has been continuously investigated by cardiological examination. Skin aging will be explored by macroscopic and microscopic evaluation. In particular, skin aging will be measured by an index of clinical aging (SCINEXA) and other complementary measures such as facial photos, standard and High Definition dermoscopy, elastography, sebumetry, in vivo and ex vivo confocal microscopy, and classical histological examinations.

Interventions

OTHERDermatological clinical examination

Clinical pictures, Dermatoscopy, Elastography, Sebumetry

OTHERBiopsy

Skin biopsy for examinations by confocal microscopy ex vivo and histopathology

OTHERConfocal microscopy in vivo

Examination by confocal microscopy in vivo

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

75 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* included in the PROOF cohort * Form consent signed

Exclusion criteria

* Past history of surgery and / or treatment of aesthetic medicine * neurological disorders * insulin-dependent diabetes, * corticosteroids or retinoids (isotretinoin, ...) \> 1 year

Design outcomes

Primary

Measure	Time frame	Description
SCINEXA score	Day 1	The aging of the skin is evaluated by a semi-quantitative composite of 19 clinical variables : the score SCINEXA

Secondary

Measure	Time frame	Description
in vivo confocal microscopy	Day 1	Skin aging evaluated by in vivo confocal microscopy
ex vivo confocal microscopy	Day 1	Skin aging evaluated by ex vivo confocal microscopy ( thickness of the epidermis with and without the stratum corneum, dermis thickness , number of sweat glands per unit volume).
histology	Day 1	Skin aging evaluated by conventional histology (thickness of the epidermis and dermis, presence and degree of elastosis , flattening of the dermo- epidermal junction)
RAMAN	Day 1	The composition of subcutaneous fat measured by ex vivo RAMAN spectroscopy

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026