Amyotrophic Lateral Sclerosis, Muscular Dystrophy, Myopathy, Orthopedic Disorder, Polyneuropathy and Mononeuropathies, Radiculopathy, Trauma Injury
Conditions
Brief summary
This study is utilizing ultrasound measurement to measure neuromuscular disease status in adult patients. The hypothesis is the by quantifying ultrasound data, it is possible that ultrasound can be utilized as a tool to determine if a disease is responding to therapy or progressing.
Interventions
None listed
Sponsors
National Institute of Neurological Disorders and Stroke (NINDS)
Beth Israel Deaconess Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* History of a well-defined, localized or generalized neuromuscular condition producing weakness or muscle atrophy, including disuse atrophy.
Exclusion criteria
* Multiple generalized neuromuscular conditions.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quantitative ultrasound data, including quantified grayscale data and backscattered acoustic data | 1 year | Ultrasound data will be collected on multiple muscles in each person. The images will then be quantified using either 1. A grayscale technique in which the images themselves are analyzed via standard image software (e.g., Adobe Photoshop) as to level of echo intensity in a pre-specific region of interest or 2. the raw quantified backscatter data is captured by the transducer, expressed as a unit of power, in the same pre-specified area of interest |
Countries
United States
Outcome results
None listed