Postoperative Pain
Conditions
Brief summary
The aim of the present study is to test that adding dexamethasone or epinephrine significantly prolongs the duration of sciatic nerve blocks with ropivacaine and that the magnitude of the effect differs among dexamethasone and epinehrine.
Detailed description
In a double-blinded trial utilizing single-injection sciatic nerve block, patients are randomly assigned to one of three groups: control: 0.5% ropivacaine adding normal saline; epinephrine: 0.5% ropivacaine adding epinephrine; dexamethasone: 0.5% ropivacaine adding dexamethasone. We assess time to first analgesic request after post-anaesthesia care unit discharge.
Interventions
DRUGDexamethasone
In dexamethasone group, dexamethasone 8 mg is added to 0.5% ropivacaine 20 ml for sciatic nerve block.
DRUGEpinephrine
Epinephrine 1:200,000 is added to 0.5% ropivacaine 20 ml for sciatic nerve block
Sponsors
Yeungnam University College of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists physical status I and II * patients undergoing elective hallux valgus repair
Exclusion criteria
* patients receiving chronic analgesic therapy * diabetes * peripheral neuropathies * psychiatric disorders * hypersensitivity to amide local anesthetics * renal disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| time to first analgesic request after postanesthetic care unit discharge | from arrival in postanesthetic care unit to 72 hours after operation | A blinded observer interview patients at arrival in postanesthetic care unit, 6 hour, 24 hour, 48 hour, 72 hour after operation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| time of recovery of motor and sensory functions on the operated foot | from arrival in postanesthetic care unit to 72 hours after operation | The time of recovery of motor (ability to move the ankle) and sensory (recovery of normal pinprick sensation) functions on the operated foot is recorded by the blinded observer at arrival in postanesthetic care unit, 6 hour, 24 hour, 48 hour, 72 hour after operation. |
Countries
South Korea
Contacts
Primary ContactSangjin Park, M.D.
Outcome results
None listed