Healthy
Conditions
Keywords
Stomach, Small bowel, Colon, MRI, Function, Gastrointestinal volumes
Brief summary
The investigators will apply non invasive Magnetic Resonance Imaging (MRI) techniques developed in Nottingham to evaluate the gastric emptying, small bowel water content, colonic gas and volumes in healthy volunteers eating three breads with different amount of gluten (none, normal, or high gluten) in three consecutive weeks.
Interventions
OTHERMRI scanners
OTHERVAS Symptom scores
Sponsors
University of Nottingham
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Aged 18-55 * Able to give informed consent
Exclusion criteria
* Unable to abstain from smoking for the duration of the study * Pregnancy declared by candidate * History declared by the candidate of pre-existing gastrointestinal disorder, including but not limited to: Inflammatory Bowel Disease, Coeliac Disease, Pancreatitis, Gallstone disease (biliary colic, cholecystitis), Diverticulitis, Cancer of the gastrointestinal tract, Irritable Bowel Syndrome * Reported history of previous resection of any part of the gastrointestinal tract other than appendix or gallbladder * Any medical condition making participation potentially compromising participation in the study e.g. diabetes mellitus, respiratory disease limiting ability to lie in the scanner * Contraindications for MRI scanning i.e. metallic implants, pacemakers, history of metallic foreign body in eye(s) and penetrating eye injury * Reported alcohol dependence * Taking any drug known to alter GI motility including mebeverine, opiates, monoamine oxidase inhibitors, phenothiazines, benzodiazepines, calcium channel antagonists during or in the 2 weeks prior to the test. (Selective serotonin reuptake inhibitors and low dose tricyclic antidepressants will be recorded but will not be an
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in gastric volume from baseline to 360 minutes after feeding | baseline and 0, 60, 120, 180, 240, 300, 360 minutes after feeding |
Secondary
| Measure | Time frame |
|---|---|
| Change in small bowel water content from baseline to 360 minutes after feeding | baseline and 0, 60, 120, 180, 240, 300, 360 minutes after feeding |
Other
| Measure | Time frame |
|---|---|
| Change in colonic total volume from baseline to 360 minutes after feeding | baseline and 0, 60, 120, 180, 240, 300, 360 minutes after feeding |
| Change in VAS for symptom scores (fullness, hunger, desire to eat, bloating, nausea, abdominal discomfort / pain) from baseline to 360 minutes after feeding | baseline, 0, 60, 120, 180, 240, 300, 360 minutes after feeding |
| Change in colonic gas volumes from baseline to 360 minutes after feeding | baseline and 0, 60, 120, 180, 240, 300, 360 minutes after feeding |
Countries
United Kingdom
Outcome results
None listed