Spinocerebellar Ataxia
Conditions
Keywords
spinocerebellar ataxia (SCA), motor evoked potential (MEP), Neuromuscular electrical stimulation (NMES), silent period, cerebellum
Brief summary
Spinocerebellar ataxia (SCA) is a hereditary disorder with movement incoordination. The ataxia performed low intra-cortical facilitation mainly due to the degenerative cerebellum. Noninvasive sensory stimulations such as peripheral electrical stimulation were reported to modulate the excitability of the motor excitability. Neuromuscular electrical stimulation (NMES) was proposed as a neuromodulation tool for the aberrant motor excitability on the SCA. This study aims to investigate the effect of NMES on the motor excitability in the SCA, and the differentiation on the central or peripheral motor excitability changed by the NMES.
Interventions
DEVICENeuromuscular electrical stimulation
All groups received an accumulated 30-minute NMES (25 Hz, on/off: 800ms/800ms) intervention on median nerve.
Sponsors
Chang Gung University
Study design
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Clinical diagnosis of Spinocerebellar ataxia * No history of epilepsy * No other neuromuscular disorder * No fracture within the last six months and restricted movement on the upper extremity * Limited trembling hand allowed for the EMG recording.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Central Motor Excitability | Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes. | Measure of changes in Central Motor Excitability by motor evoked potential and silent period that are measured by transcranial magnetic stimulation. |
| Peripheral Motor Excitability | Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes. | Measure of changes in peripheral motor excitability by Maximum M wave and H reflex |
Countries
Taiwan
Outcome results
None listed