Hepatobiliary Tract Adenomas and Carcinomas, Liver Cancer
Conditions
Keywords
liver, ischemia, reperfusion
Brief summary
The investigators would like to study whether Sirtuin 1 (SIRT1) plays a cytoprotective role in liver ischemia/reperfusion, and ultimately to develop therapeutic strategies to improve hepatic function of patients with liver diseases.
Detailed description
If asked to participate in this research study, it is because a liver resection/liver transplantation surgery has been scheduled. During the procedure a small section will be collected for additional testing of Sirtuin 1. In addition, information concerning the liver disease, laboratory and pathology results after surgery will be collected by the investigators.
Interventions
PROCEDUREHepatocellular carcinoma
Participants undergoing a liver resection/liver transplantation surgery. During the liver surgery a small piece of tissue will be removed to undergo additional laboratory testing.
Sponsors
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
University of Florida
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* liver resection \> 2 segments, * plate count \> 100 x 109/L, and * prothrombin activity \>60%.
Exclusion criteria
* liver cirrhosis, * portal hypertension, * steatohepatitis or severe steatosis, * patients receiving additional ablation therapies, * laparoscopic resection, and * simultaneous extrahepatic procedures such as colorectal resection or pancreatoduodenectomy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biochemical analysis of sirtuin1 from liver tissues during liver surgery | 30 minutes during liver surgery |
Countries
United States
Outcome results
None listed