Efficacy of Preoperative Intravenous Dexamethasone in Primary Total Knee Arthroplasty

Efficacy of Preoperative Intravenous Dexamethasone in Controlling Postoperative Pain After Primary Total Knee Arthroplasty: A Randomized Double-blinded Controlled Trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02102815

Acronym

TKA

Enrollment

100

Registered

2014-04-03

Start date

2014-05-31

Completion date

2016-06-30

Last updated

2019-01-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Keywords

total knee arthroplasty, pain control, dexamethasone, steroids

Brief summary

To determine efficacy of preoperative IV dexamethasone for postoperative pain control after TKA.

Detailed description

Preoperative intravenous over 0.1 mg/kg of dexamethasone could be reduced pain after primary TKA.

Interventions

DRUGDexamethasone

Dexamethasone 0.15mg/kg mixed with NSS up to 50 mL IV slowly push over 5 minutes

DRUGNormal saline

NSS 50 mL IV slowly push over 5 minutes

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

50 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty * 50-85 years old * ASA class 1-3

Exclusion criteria

* Unable to perform spinal anaesthesia * History of drug allergies: steroids * Renal impairment (CrCl \<30 mL/min) * Liver impairment * Cognitive function disorders * Poor controlled DM (HA1C \> 7.5) * Morning DTX at operative day \> 180 mg% * Received corticosteroids within 3 months before surgery

Design outcomes

Primary

Measure	Time frame	Description
post-operative pain	48 hours	measured with VAS for pain, drugs for relief pain

Secondary

Measure	Time frame	Description
complication of preoperative dexamethasone	2 weeks	measured with wound complication, blood sugar level
inflammatory level	48 hours	CRP level
Functional knee score	3 month	measured with WOMAC, KSS
post-operative nausea and vomiting	48 hours	measured with amount of nausea/vomiting and drugs requiring for fixed its.

Other

Measure	Time frame	Description
Knee range of motion	3 months	measuring range of motion with goniometer

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026