Furcation Defects, Periodontal Disease
Conditions
Keywords
microsurgery, furcation defects, periodontal disease, enamel matrix proteins, bone substitutes
Brief summary
This clinical study compared a conventional surgical technique (CST) and a minimally invasive surgical technique (MIST) in the regenerative treatment of mandibular furcation defects.
Detailed description
Using a split-mouth design, fifteen patients with bilateral class II and III furcation defects were treated with MIST (Test Group) or CST (Control Group). Furcation defects in both groups were filled with anorganic bovine bone (ABB) and enamel matrix derivative (EMD). Patient-centered outcomes including analyses of pain, discomfort, edema, hematoma, root hypersensitivity and daily activities interference were recorded using a Visual Analogue Scale seven days after surgeries. Clinical and radiographic parameters were assessed at baseline and 6 months postoperatively. Data were statistically analysed.
Interventions
DEVICEAnorganic Bovine Bone
used to improve periodontal regenerative procedures.
DEVICEEnamel Matrix Derivative
used to improve periodontal regenerative procedures.
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
(I) subjects with a diagnosis of periodontitis; (II) presence of one pair of contralateral mandibular molars with buccal / lingual furcation defects; (III) non-smokers; (IV) plaque index \< 20%.
Exclusion criteria
(I) patients that presented systemic disease; (II) had taken antibiotics in the past 6 months prior to surgery; (III) pregnant women or lactating mothers; (IV) molars with periapical disease; (V) cervical restorations or prosthesis closer than 1 mm to fornix; (VI) lingual furcation defects presenting gingival recession (GR)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Horizontal clinical attachment level (HCAL) | baseline and 6 months after surgical procedure | The clinical measure HCAL was assessed and recorded by an experienced periodontist, blinded to the procedures to assess the efficacy of surgical procedures. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain Scores on the Visual Analogue Scale | 7 days after surgery | — |
| Discomfort Scores on the Visual Analogue Scale | 7 days after surgery | — |
| Edema Scores on the Visual Analogue Scale | 7 days after surgery | — |
| Hematoma Scores on the Visual Analogue Scale | 7 days after surgery | — |
| Root Hypersensitivity Scores on the Visual Analogue Scale | 7 days after surgery | — |
| Daily Activities Interference Scores on the Visual Analogue Scale | 7 days after surgery | — |
| Vertical clinical attachment level (VCAL) | baseline and 6 months | The clinical measure HCAL was assessed and recorded by an experienced periodontist, blinded to the procedures to assess the efficacy of surgical procedures. |
| Probing pocket depth (PPD) | baseline and 6 months | The clinical measure HCAL was assessed and recorded by an experienced periodontist, blinded to the procedures to assess the efficacy of surgical procedures |
| Gingival recession | baseline and 6 months | The clinical measure HCAL was assessed and recorded by an experienced periodontist, blinded to the procedures to assess the efficacy of surgical procedures |
Other
| Measure | Time frame | Description |
|---|---|---|
| Digital subtraction radiography density gain | baseline and 6 months | The radiographs were obtained with the paralleling technique employing an x-ray unit and a digital sensor . Customized radiographic holders for each patient . Digital subtraction radiographs (DSR) were performed using a specific software. All pairs of baseline and 6-month radiographs for each treated site were then subtracted. Standardized regions of interest (ROIs) were select for each subtracted digital image: (1) placed in the bone's most coronal and central aspect of the furcation defect; and (2) placed at a distant untreated site acting as a radiographic control. The ROIs were not superimposed on any portion of the tooth surface. A software (Image Tool for Windows, Version 3.0, USA) was used to assess radiographic density changes that occurred in ROIs. |
Countries
Brazil
Outcome results
None listed