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Study of the Effect of Transcranial Stimulations in Aphasic Subject Within a Year of Their Stroke

Etude de l'Effet de Stimulations transcrâniennes en Courant Continu (tDCS) Sur Les Performances en dénomination Chez le Sujet Aphasique à Moins d'un an de Son Accident Vasculaire cérébral : Comparaison de 5 Configurations de Stimulation

Status
Terminated
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02101398
Enrollment
5
Registered
2014-04-02
Start date
2014-10-02
Completion date
2016-07-31
Last updated
2025-09-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aphasia, Stroke

Keywords

tDCS, Stroke, Aphasia, Naming

Brief summary

The aim of this work is to study the effect of transcranial direct current stimulation combined with naming therapy in acute and post-acute stroke comparing four bihemispheric positioning electrodes to a sham condition.

Detailed description

TDCS have shown a positive effect on clinical outcome in naming treatment in aphasic subjects however some aspects as the positioning of the electrodes on the head are still unclear. That is why we compare the effects of four different positionings of the electrodes (two anterior over Broca's area and its homologue and two posterior over Wernicke's area and its homologue) to a sham stimulation in order to observe if a more important effect of one or another positioning could be found.

Interventions

DEVICEeldith DC-stimulator, configuration F7A

tDCS will be delivered during a 20 minutes speech-language therapy session

DEVICEeldith DC-stimulator, configuration F7C

tDCS will be delivered during a 20 minutes speech-language therapy session

DEVICEeldith DC-stimulator, configuration T5A

tDCS will be delivered during a 20 minutes speech-language therapy session

DEVICEeldith DC-stimulator, configuration T5C

tDCS will be delivered during a 20 minutes speech-language therapy session

DEVICEeldith DC-stimulator, configuration Sham

Sham tDCS will be delivered during a 20 minutes speech-language therapy session

Sponsors

Institut National de la Santé Et de la Recherche Médicale, France
Lead SponsorOTHER_GOV

Study design

Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* man or woman of 18 years and older * aphasic patient following a first left hemispheric stroke * BDAE 3.0 aphasia score \> or = to 1 * stroke within 3 to 12 months before inclusion in the study * mother tongue = French * right handedness * signed informed consent

Exclusion criteria

* history of other neurologic pathologies * epileptic seizure within 2 months before inclusion * dementia * bilingual patient (2 mother tongues) * history of cranial surgery * presence of intracerebral metallic material * unauthorized molecules at inclusion : sulpiride, rivastigmine, dextromethorphan, carbamazepine, flunarizine, levodopa * pregnant, parturient or lactating woman

Design outcomes

Primary

MeasureTime frame
Percentage of improvement of picture namingBefore stimulation and immediately after stimulation

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026