Effects of Magnesium Sulfate on Onset and Duration of Low Dose Rocuronium

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02100293

Enrollment

Registered

2014-03-31

Start date

2013-10-31

Completion date

2014-12-31

Last updated

2016-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intubation Condition, Observation of Neuromuscular Block, Surgical Condition

Keywords

magnesium sulfate, rocuronium

Brief summary

This study aims to evaluate effects of magnesium sulfate on onset and duration of low dose rocuronium, intubation condition and surgical condition.

Interventions

DRUGmagnesium sulfate 30 mg/kg

Patients in each group received the magnesium sulfate 30 mg/kg for 2 min in 0.9% normal saline (total volume 100 ml) intravenously for 5 min before induction of anesthesia

DRUGsaline

Patients in each group received 0.9% normal saline (total volume 100 ml) alone intravenously for 5 min before induction of anesthesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* 18-75 yr American Society of Anesthesiologists physical status 1 or 2, BMI of 20-24.9 kg/m2 scheduled for elective laryngeal microsurgery

Exclusion criteria

* severe respiratory or cardiac disease hepatic or renal function impairment neuromuscular disease on medications affecting neuromuscular function with known allergy to the drugs

Design outcomes

Primary

Measure	Time frame	Description
onset time of rocuronium	from injection of rocuronium to T1 suppression more than 95% up to 10 minutes	from injection of rocuronium to T1 suppression more than 95% up to 10 minutes

Secondary

Measure	Time frame
maximal suppression time and duration of rocuronium	time from the injection of rocuronium to T1 maximal suppression time and reversal of T1 25% up to 1 hours

Other

Measure	Time frame	Description
intubation condition	intubation condition during induction of anesthesia up to 10 minutes	We scored intubation condition on the basis of 4 items, laryngoscopy, vocal cord position, moving of limbs, and coughing.
surgical condition	intraoperative surgical condition	to score a surgical condition according to 7 point likers scale
postoperative sore throat	postoperative sore throat up to 4 hours	—

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026