Multiple Sclerosis
Conditions
Keywords
physical activity, exercise guidelines, multiple sclerosis
Brief summary
The proposed project will evaluate two methods of implementation of the new Physical Activity Guidelines (PAGs) for Adults with Multiple Sclerosis (MS) living in two Ontario communities. The investigators will also determine if following the PAGs will improve aspects of fitness, function, quality of life and risk for cardiometabolic disease in this population. The investigators hypothesize that adherence to the PAGs will be higher in people who have been referred directly to a community-based exercise program, and that this greater adherence to physical activity will be associated with greater improvements in fitness, function and quality of life. This randomized controlled trial will provide important information on how best to implement physical activity recommendations within the community setting; this information will be translated to key stakeholders during the final stages of the project.
Interventions
OTHERDirect Referral to physical activity
Participants randomized to the Direct Referral to Physical Activity Arm will be provided with a referral to a physical activity program in their community and will be closely monitored in this program for 16 wks.
Sponsors
McMaster University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of MS with mild-moderate disability (EDSS 1-7) * Aged 18-60 * Medical clearance to participate in physical activity
Exclusion criteria
* current participation in regular physical activity (at least twice-weekly) * other serious medical condition that might impair ability to participate in strength or aerobic exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Adherence to the Physical Activity Guidelines | 3 years | Adherence to the physical activity guidelines will be analyzed by having participants fill in a weekly physical activity log that will be sent to them by email. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood markers of cardiovascular disease risk | At baseline and after the 16 week intervention | blood lipid panel, HbA1c, fasting glucose |
| Physical Fitness | At baseline and after the 16 week intervention | Peak oxygen uptake, maximum muscle strength, bodyweight |
| Perceived Quality of Life | At baseline and after the 16 week intervention | Multiple Sclerosis Quality of Life (MSQoL) scale |
| Fatigue | At baseline and after the 16 week intervention | Multiple Sclerosis Fatigue Impact Scale (MSFIS) |
| Mobility | At baseline and after the 16 week intervention | 25ft walk test |
Countries
Canada
Outcome results
None listed