Effects of Coffee Consumption on Glucose Metabolism

Coffee and Glucose Metabolism: Clinical, Crossover and Randomized Glucose Disposal Assay Using Stable Isotopes

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02099929

Enrollment

Registered

2014-03-31

Start date

2012-06-30

Completion date

2013-12-31

Last updated

2014-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Coffee, Glucose, Insulin, Diabetes, Type 2 Diabetes Mellitus

Brief summary

Epidemiological studies have shown an inverse association between coffee consumption and risk of type 2 diabetes mellitus (T2DM). However the experimental studies that analysed the mechanisms are limited. This project aims to assess the effects of coffee consumption on glucose metabolism, using stable isotope tracer (13C-glucose) to explain the possible metabolic mechanisms involved on the reduced risk for T2DM.

Detailed description

This is a crossover randomized clinical trial that has been studying 14 male healthy young adults, who were enrolled five treatments: coffee with sugar, coffee without sugar, decaffeinated coffee without sugar and two controls (water with and without sugar). The stable isotope minimal model protocol with oral glucose administration (Oral Dose Intravenous Label Experiment - ODILE) was performed. The use of ODILE methodology permits separation of the glucose absorbed and removed from the circulation increasing the accuracy and the effectiveness of glucose uptake and insulin sensitivity (Bluck et al., 2006).

Interventions

OTHERCoffee with Sugar

300mL of Coffee with 30g of Sugar

OTHERCoffee without Sugar

300mL of Coffee without Sugar

OTHERDecaffeinated Coffee without Sugar

300mL of Decaffeinated Coffee without Sugar

OTHERWater with Sugar

300mL of Water with 30g of Sugar

OTHERWater without Sugar

300mL of Water without Sugar

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

MALE

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Male healthy young adults (18 - 50 years old); * Body mass index (BMI) between 18.5 - 28.0 kg/m²; * No weight changes (≥ 5 kg) in the last 3 months; * Not take any pills/drugs that alter metabolism, appetite and sleep; * Not have sleep disorders; * Not have donated blood in the last 3 months; * Regular breakfast consumption (≥100 kcal ingested up to 2 hours after waking ≥4x/week); * Being a habitual coffee consumer (≥100mL ≥5x/week).

Exclusion criteria

* Diagnosis of anemia, metabolic and heart diseases; * Previous sudden fainting and convulsions; * Any drugs and tobacco consumption; * Consumption of more than 500mg of caffeine / day (5 cups of coffee, tea and cola soft drinks).

Design outcomes

Primary

Measure	Time frame	Description
ODILE minimal model analysis	-10, 0, 30, 60/0, 15, 30, 45, 47, 49, 51, 53, 55, 57, 59, 61, 65, 70, 75, 80, 85, 90, 100, 115, 135, 165, 195, 225 minutes.	The stable isotope minimal model protocol with oral glucose administration (Oral Dose Intravenous Label Experiment - ODILE)

Secondary

Measure	Time frame	Description
Glucose metabolism	-10, 0, 30, 60/0, 15, 30, 45, 47, 49, 51, 53, 55, 57, 59, 61, 65, 70, 75, 80, 85, 90, 100, 115, 135, 165, 195, 225 minutes.	Glucose and Insulin levels, and Insulin sensitivity indices.

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026