Coronary Artery Disease, Ischemic Heart Disease
Conditions
Keywords
OCT, Coronary, Stenting
Brief summary
Optical coherence tomography (OCT) has been recently studied for evaluation of coronary stenting. Because of high resolutions, several reports have shown that OCT is appropriate for evaluating neointimal tissue after coronary stent implantation. Also, the strut coverage and the characterization of neointimal tissue can be accurately evaluated. Furthermore, OCT-defined coverage of a stent strut was proposed to be related with clinical safety in drug-eluting stents-treated patients. Therefore, the investigators will evaluate the appropriateness of currently using coronary stents (e.g. Sirolimus eluting stent, Paclitaxel-eluting stent, Zotarolimus-eluting stent, Everolimus-eluting stent, Biolimus eluting stent, EPC(endothelial progenitor cell) Capture stent, etc) based on the findings of OCT. Additionally, the investigators will evaluate neointimal hyperplasia, malposition or strut coverage to decide the differences in the stent characteristics, the duration of antiplatelet use, and the differences according to the clinical presentations.
Interventions
DEVICEcoronary stents
e.g. Sirolimus eluting stent, Paclitaxel-eluting stent, Zotarolimus-eluting stent, Everolimus-eluting stent, Biolimus eluting stent, EPC(endothelial progenitor cell) Capture stent, etc
Sponsors
Yonsei University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients with coronary stents 2. Patients who will have coronary stents because of coronary artery stenosis
Exclusion criteria
1. Hemodynamically unstable patients 2. Ostial lesions that begin within 15 mm of the left main coronary artery 3. Lesions with diameter more than 4 mm 4. Patients with allergy to antiplatelet agent (asprin or clopidogrel) 5. Patients with hepatic dysfunction (Liver enzyme 3 times the upper limit of normal) 6. Pregnant and lactating patients 7. Patients with life expectancy less than 1 year
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| OCT findings (stented lesions, native vessels) | at index PCI, at follow-up coronary angiography (3, 6, 9 or 12 months and at the time clinically indicated) | — |
| Clinical outcomes | up to 10 years | Death, Cardiac death, Stent thrombosis, Myocardial infarction, Target-lesion revascularization, Target-vessel revascularization |
| Comparison of OCT findings with physiologic findings | at index PCI, at follow-up coronary angiography (3, 6, 9 or 12 months and at the time clinically indicated) | — |
Countries
South Korea
Contacts
Primary ContactMyeong ki Hong, MD, PhD
Outcome results
None listed