The Efficacy of Steroid Therapy in Vestibular Neuritis

The Efficacy of Steroid Therapy in Vestibular Neuritis Confirmed by Head Impulse Test: Prospective Randomized Controlled Study

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02098330

Enrollment

Registered

2014-03-28

Start date

2014-03-31

Completion date

2015-06-30

Last updated

2019-01-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vestibular Neuritis

Keywords

Vestibular neuritis, Vertigo, Head impulse test, Steroid

Brief summary

The purpose of this study was to compare the treatment effectiveness of steroid therapy for vestibular neuritis by using video head impulse test.

Detailed description

This study was a prospective, randomized controlled study. The enrolled vestibular neuritis patients were randomized to conservative treatment or steroid treatment when they are diagnosed with caloric test. After initial vestibular work-up including caloric, video head impulse tests, and a questinnaire (DHI), the patient was examined with the same tests again at 6 months later. The efficacy of steroid for the patients with vestibular neuritis would be determined by the comparison of the data of each group.

Interventions

DRUGGinkgo biloba & Methylprednisolone

Ginkgo biloba 160 mg/day (per oral, 80 mg twice a day) for 1 month. Methylprednisolone 48 mg/day(per oral, once a day for first 9 days. And then methylprednisolone tapering was started every 2 days. The entire duration of methylprednisolone treatment was 14 days.

DRUGGinkgo biloba

Ginkgo biloba 160 mg/day (per oral, 80 mg twice a day) for 1 month.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Ages over 18 years * Acute vertigo that occurred within 7 days * The spontaneous nystagmus should be detected * Caloric weakness over 20%

Exclusion criteria

* Suspicious or verified a central nervous system lesion * If the patient has denied. * Other otologic disease (acute/chronic otitis media, otosclerosis, etc) * The patient with history of otologic surgery * The patient with history of brain surgery

Design outcomes

Primary

Measure	Time frame	Description
The improvement in vestibular function test (caloric & videop HIT) after treatment	The first results were collected at initial diagnosis. And following results were collected 6 months after the first exam.	The effectiveness of steroid therapy was determined by comparing the improvement of vestibular function (the degree of canal paresis by caloric test; gain and presence of refixation-saccade by video HIT test).

Secondary

Measure	Time frame	Description
The improvement in dizziness handicap inventory after treatment	The first results were collected at initial diagnosis. And following results were collected 6 months after the first exam.	The effectiveness of steroid therapy was determined by comparing improvement of subjective symptoms (symptom score by DHI) in each group.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 10, 2026