Knee Osteoarthritis
Conditions
Keywords
Knee Pain, Community Study, Knee Osteoarthritis, Risk Factors
Brief summary
The focus of the study is to determine the prevalence and variance of self-reported knee pain characteristics in a community-derived sample of adults aged 40 years and over. It will also identify characteristics such as structural changes of osteoarthritis of the knee as well as physiological parameters and blood and urine biomarkers.
Detailed description
Number of participants: Part I: questionnaire to 40,000 people aged 40 years and over (giving an expected 10,000 respondents) Part II: 400 participants.
Interventions
None listed
Sponsors
Arthritis Research UK
University of Nottingham
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Aged 40 years and over
Exclusion criteria
* Inability to give informed consent * Terminal or mental illness * Pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Knee Pain Phenotypes | up to 12 months | The prevalence of the different knee pain phenotypes, provided by specific pain questionnaires. This will include the Intermittent and Constant Osteoarthritis Pain Questionnaire (ICOAP), the Pain Catastrophizing Scale (PCS) and the PainDetect (for neuropathic pain). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Other Risk Factors | up to 12 months | The risk factors for each knee pain phenotype, including age, gender, pain elsewhere, the Hospital Anxiety and Depression Scale (HADS), the pain catastrophizing scale and presence of osteoarthritis risk factors (BMI, finger ratio (2D4D), finger nodes, knee alignment) will be determined from the questionnaires. |
Countries
United Kingdom
Outcome results
None listed