Knee Osteoarthritis Risk in Retired Professional Footballers

An Investigation of the Prevalence of Knee Osteoarthritis and Pain in Retired Professional Male Footballers in the United Kingdom

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02098044

Enrollment

1300

Registered

2014-03-27

Start date

2014-11-30

Completion date

2018-12-31

Last updated

2018-05-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the Knee

Keywords

knee osteoarthritis, epidemiology, risk factors, prevalence, professional football

Brief summary

The OA and Football Study is an epidemiological study designed to establish the prevalence of knee osteoarthritis in retired professional footballers. The study will also identify the key risk factors associated with knee osteoarthritis. The study is comprised of three phases: Phase I involves the dissemination of a questionnaire (demographic details, players history, injury and surgery and other known risk factors of OA), Phase II is a radiographic study that involves x-rays in a sample of footballers both with and without knee pain and Phase III is a case control study which will compared retired professional footballers with age-matched controls recruited from the general population in the East Midlands region.

Detailed description

Number of Participants: Phase I: 1000 Phase II: 855 Phase III: 500 Primary outcome: The questionnaire will contain player specific information and will include validated outcome measures such as the health status questionnaire as well as self-reported pain, recall of injury and surgery history. The results of the questionnaire will be exported firstly to Excel and subsequently, into MS Access as part of a managed database.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

40 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

Phase I Inclusion Criteria: • All current or retired professional male footballers (Registered with the Professional Footballer Association (age range 40 -80) Phase II Inclusion Criteria: * Professional footballers both with and without a history of knee pain knee OA or knee surgical history * No contraindications of the affected joint such as gout or rheumatoid arthritis * Willingness to participate in a clinical assessment of the knee and provision of blood samples. Phase III Inclusion Criteria for controls: * Over the age of 40 (age range 40 - 80) * Both with and without a history of knee pain over at least the last 1 year * No history of significant trauma, injury or surgery to the lower limb * American College of Rheumatology (ACR) classification of OA based on physical examination and clinical presentation: Pain in the knee and three of the following; over the age of 50, less than 30 minutes of morning stiffness, crepitus on active motion, bony tenderness, bony enlargement and no palpable warmth of synovium. Phase I

Exclusion criteria

* Not a registered professional footballer (current or past) * Inaccurate information (discrepancy with questionnaire information compared to other football records. This will be verified by the co-investigator, Dr Fernandes and Mr Sanjay Parekh) * Incomplete questionnaire or duplicate questionnaire. Phase II

Design outcomes

Primary

Measure	Time frame	Description
Self Reported Knee Pain	up to 12 months	Questionnaire data with regards to acute knee pain, type of pain, duration of pain and knee injury and knee surgery history.

Secondary

Measure	Time frame	Description
Radiographic Knee OA changes	up to 12 months	Bilateral x rays using standardised rigs for 2 views. Postero-anterior view (30 degrees flexion, weight bearing) and skyline views.

Countries

United Kingdom

Outcome results