The Clinical Study on Combizym and Bifidobacteri to Prevent the Recurrence of Colon Polyps

A Randomized Controlled Study on Combizym and Bifidobacteria to Prevent the Recurrence of Colon Polyps

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02097394

Enrollment

200

Registered

2014-03-27

Start date

2013-06-30

Completion date

2020-06-30

Last updated

2020-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bifidobacteri, Colon Polyps, Combizym

Brief summary

The study hypothesis is whether digestion enzyme(Combizym) and intestinal flora drugs(Bifidobacteria) can decease recurrence rate of colon polyps

Detailed description

Colon polyps has high recurrence rate in the digestion diseases. However, the reasons are not clear. The possible reasons for the recurrence of colon polyps include intestinal inflammation (e.g., Ulcerative colitis), intestinal flora imbalance (the benefit intestinal bacteria reduced, which lead to diarrhea or constipation), long-term indigestion. The investigators propose to examine whether digestion enzyme (Combizym) and intestinal flora drugs(Bifidobacteria) can decease recurrence rate of colon polyps

Interventions

DRUGCombizym

Combizym( 1 tablet, po, tid)

DRUGBifidobacteri

Bifidobacteri (2 tablet, po, tid)

DRUGCombizym + Bifidobacteri

Combizym( 1 tablet, po, tid) + Bifidobacteri (2 tablet, po, tid)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

-Patients who have cutted colon polyps in one month, and the diagnosis were proved by pathological analysis

Exclusion criteria

* have organic or other functional disease * pregnant or breast-feeding

Design outcomes

Primary

Measure	Time frame	Description
recurrence of colon polyps	one year	The whole patients need be examined by colonoscopy one year later. The recurrence rate of colon polyps will be acquired in different arms

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026