Hypertension
Conditions
Brief summary
* Bisphenol A(BPA) is an endocrine disrupting chemical, which mimics the action of estrogen. * Previous studies reported that BPA exposure is associated with increased risk of cardiovascular diseases. * Exposure to BPA occur mainly through oral route, and epoxy coating of canned food is one of the well established source. * The investigators hypothesis is that increased BPA exposure from canned beverage would disrupt normal physiology in a short term. * In the present trial the investigators are to investigate whether increased BPA exposure by consuming canned beverage actually affect cardiovascular indices and epigenetic feature. * For this aim, the investigators will conduct a cross-over trial.
Interventions
OTHERCan 1
drink the beverage in a can and a glass bottle
OTHERCan 2
Consume two canned beverage
OTHERGlass
consume two glass bottled beverage
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
60 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Reside in Seoul * Who provided Informed consent
Exclusion criteria
* Who has cancer * Who has disease or disorder of liver, nervous system, endocrine system, cardiovascular system * Who does not provieded informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood Pressure | 2 hours after consuming beverage |
Secondary
| Measure | Time frame |
|---|---|
| Percent DNA methylation | 2 hours after consuming the beverage |
| Heart Rate Variablility | 2 hours after consuming the beverage |
Countries
South Korea
Outcome results
None listed