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Sevoflurane Versus Desflurane for Catheter-related Bladder Discomfort

Comparison of the Effects of Sevoflurane and Desflurane on Prevention of Catheter-related Bladder Discomfort

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02096224
Enrollment
108
Registered
2014-03-26
Start date
2014-05-31
Completion date
2014-07-31
Last updated
2014-10-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Catheter Site Discomfort, Complications, Urinary Bladder Neoplasms

Brief summary

We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.

Detailed description

The mechanism of catheter-related bladder discomfort is thought to be related to the muscarinic receptor. The volatile anesthetics such as sevoflurane and desflurane are known to block the muscarinic receptor in different ways. We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.

Interventions

DRUGSevoflurane

Sevoflurane will be used.

DRUGDesflurane

Desflurane will be used

Sponsors

Seoul National University Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* Patients scheduled for transurethral bladder excision under general anesthesia * ASA I-III

Exclusion criteria

* Bladder outflow obstruction * Overactive bladder * End-stage renal disease * Neurogenic bladder * Heart failure * Arrhythmia * Morbid obesity * Use of chronic analgesic medication * Hepatic disease * Pulmonary disease * Psychiatric disease

Design outcomes

Primary

MeasureTime frameDescription
Catheter-related bladder discomfort24 hour postoperativelyCatheter-related bladder discomfort will be measured for 24 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe).

Secondary

MeasureTime frameDescription
Catheter-related bladder discomfort0, 1, 6 and 24 hour postoperativelyCatheter-related bladder discomfort will be measured at 0, 1, 6 and 24 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe).
Nausea0, 1, 6 and 24 hour postoperativelyThe degree of nausea will be assessed as none, mild, moderate and severe at 0, 1, 6 and 24 hour postoperatively.
Vomiting0, 1, 6 and 24 hour postoperativelyThe degree of vomiting will be assessed as none, mild, moderate and severe at 0, 1, 6 and 24 hour postoperatively.
Dry mouth0 houe after admission of operating roomDry mouth after the admission of operating room will be assessed. (score:0-10)

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 14, 2026