Acute Kidney Injury Biomarkers: Diagnosis and Application in Pre-operative Period of Liver Transplantation

Conditions

Acute Kidney Injury

Keywords

patients undergoing the liver transplantation, acute kidney injury

Brief summary

Acute kidney injury (AKI), is a common complication of patients undergoing liver transplantation. Timing and definition of AKI, usually based on serum creatinine, have been inaccurate and inconsistent. We hypothesized that the pattern of novel biomakers elevation could be a prognostic tool to provide information on the risk of progression of AKI, the need for RRT and mortality.

Monique de Oliveira Branquinho, Luciana Severo BRANDãO, Gillene Santos Ferreira, Ramon Antônio Oliveira, Camila Aparecida Benedito Rodrigues de Lima

2025-09-10

10.65034/bjnabstract-cpn25504

Comprehensive biomarker assessment for predicting severe acute kidney injury and need of kidney replacement therapy in liver transplantation patients

Camila Lima, Gillene Santos Ferreira, Maria de Fátima Fernandes Vattimo, Luciana Haddad, Luíz Marcelo Sá Malbouisson et al. (8 authors)

Renal Failure2024-09-173 citations

10.1080/0886022x.2024.2402076

Early detection of acute kidney injury in the perioperative period of liver transplant with neutrophil gelatinase-associated lipocalin.

Lima C, de Paiva Haddad LB, de Melo PDV, Malbouisson LM, do Carmo LPF, D'Albuquerque LAC, Macedo E.

2019-10-1515 citations

10.1186/s12882-019-1566-9

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

No

Inclusion criteria

* Older than 18 years * Reception liver transplantation

Exclusion criteria

* CKD stage 4 / 5 * Combined organ transplants * Patients receiving dialysis before liver transplant operation

Design outcomes

Primary

Measure	Time frame	Description
Development of Acute Kidney Injury based on novel biomarkers	within 7 days	Compare the timing for diagnosis of AKI comparing novel biomarkers and serum creatinine defined by Kidney Disease Improving Global Outcomes. In addition, we aim to evaluate if the pattern of elevation of the novel biomarkers provide information on progression and severity of AKI.

Secondary

Measure	Time frame	Description
Short and long term renal outcomes	1 year	renal function and need for RRT
Association of urine chemistry and microscopy to predict acute kidney injury	within 7 days of liver transplantation	Association of urine chemistry and microscopy with novel biomarkers to predict AKI diagnosis and progression

Countries

Brazil

Outcome results