Healthy Volunteers
Conditions
Keywords
soluble phosphate, phosphorus metabolism, calcium metabolism, bone metabolism, human study
Brief summary
The study was conducted to investigate the effect of soluble phosphate in combination with different calcium doses on calcium and phosphorus metabolism and further physiological parameters in healthy subjects. The main aim of the study is to investigate the influence of a soluble phosphate supplementation on the fasting blood phosphate concentration and the dependency of an additional calcium intake.
Interventions
DIETARY_SUPPLEMENTP1000/Ca0
22 subjects consume for 8 weeks a beverage enriched with phosphate \[1g phosphorus/d\]
DIETARY_SUPPLEMENTP1000/Ca500
22 subjects consume for 8 weeks a beverage enriched with phosphate \[1 g phosphorus/d\] and calcium \[0,5 g calcium\]
DIETARY_SUPPLEMENTP1000/Ca1000
22 subjects consume for 8 weeks a beverage enriched with phosphate \[1 g phosphorus/d\] and calcium \[1 g calcium\]
DIETARY_SUPPLEMENTPlacebo
all participants consume two weeks before intervention the beverage without phosphate and calcium
Sponsors
University of Jena
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* age between 18-60 years * physical health
Exclusion criteria
* postmenopausal women * kidney diseases * diabetes mellitus * metabolic diseases * osteoporosis * intake of dietary supplements * pregnancy and lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting phosphate concentration in blood | 8 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Calcium and phosphorus metabolism | 8 weeks | * parameters of phosphate and calcium metabolism (1,25-OHD; 25-OHD;FGF23;PTH) * parameters of bone formation and resorption (osteocalcin, P1NP, CTX) * minerals in plasma, faeces and urine |
Countries
Germany
Outcome results
None listed