The Interaction Between Appetite Hormones

Conditions

Obesity

Brief summary

Glucagon Like Peptide (GLP) -1 affects metabolic response corrected for weight change

Detailed description

Many obese people have had several successful weight losses, however very few can maintain the weight loss over a longer period (e.g. one year) Therefore, we want to investigate the metabolic response and the importance for maintenance of weight loss in obese people, who lost at least 7, 5 % body weight by low calorie diet followed by 52 weeks of diet weight maintenance with or without supplement of GLP-1.

Brethvad AO, Zakariassen HL, Holt J, Lundgren JR, Jakobsen A, Hartmann B, Lehmann EW, Kissow H, Holst JJ, Madsbad S, Torekov SS, Holst B.

2023-03-168 citations

10.1016/j.metabol.2023.155534

Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With Cardiovascular Disease.

Akawi N, Checa A, Antonopoulos AS, Akoumianakis I, Daskalaki E, Kotanidis CP, Kondo H, Lee K, Yesilyurt D, Badi I, Polkinghorne M, Akbar N, Lundgren J, Chuaiphichai S, Choudhury R, Neubauer S, Channon KM, Torekov SS, Wheelock CE, Antoniades C.

2021-05-0177 citations

10.1016/j.jacc.2021.03.314

Interventions

OTHERGLP-1

GLP-1

DIETARY_SUPPLEMENTlow calorie diet

low calorie diet

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 64 Years

Healthy volunteers

Yes

Inclusion criteria

* BMI \> 30 and \< 40 (kg/m2) * Healthy

Exclusion criteria

* Other known illness * Medicine that affects glucose- and lipid metabolism, appetite or food intake * Pregnancy * Breast feeding

Design outcomes

Primary

Measure	Time frame
Change in hormone level corrected for weight change	Baseline and week 52

Countries

Denmark

Outcome results

None listed